RP4 Server Host / NAS build (4 x SATA Drives?)

Saw NetworkChuck’s video on how to build an RP4 NAS device on JP’s Telegram the other day, which looks amazing, but wanted input from someone above my skill level on shooting for the moon and doing a 4 x SATA Hat on an RP4. (4 drives attached to an RP4 configured like an NAS for storage, and file sharing/hosting)

Is there a limit realistically on the size of the drives (can it handle 2, 3 or 4 x 8TB drives?)
What are some of the critical options or do’s/don’t do’s that you can think of on this type of a build?


Any input greatly appreciated, thanks!