Tails is a non-persistent distro, which runs out of a USB stick - regardless of the computer you’re using. Qubes has persistence (you can store files and settings), but it requires a serious system with at least 32GB of RAM, due to its many virtual machines.
As for me, I don’t need to go into “overkill mode” - which is what the two distros provide. For now, I’m settling for a reasonably secured distro, either Ubuntu or a Fedora/CentOS one.